Acute dental periapical abscess and new-onset atrial fibrillation: A nationwide, population-based cohort study

Abstract Funding Acknowledgements Type of funding sources: None. Background There are limited data on whether there is an association between hospitalisation with dental periapical abscess and new-onset atrial fibrillation (AF) which independent main cardiovascular risk factors. Purpose To investigate AF. Methods A retrospective cohort study from a national database patients hospitalised in 2013 (3.4 million patients) at least five years follow up, unless deceased. International Classification Diseases (ICD) codes were used to compare the developing AF for adults without abscesses using univariate multivariable analysis hazard ratios (HR). Results In total, 4,693 classified as having abscess, 435 (9.27%) developed AF, compared 326,241 (10.69%) over mean follow-up 4.8 ± 1.7 years. Multivariable indicated that acted predictor new onset (p < 0.01). Conclusions An increased was identified individuals abscess. Careful up severe, acute infections needed incident well investigations possible mechanisms linking these conditions. Predictors during FU Univariate Multivariate HR, 95%CI P Age, 1.077 (1.076-1.077) <0.0001 1.076 (1.075-1.076) Gender (male) 1.640 (1.629-1.651) 1.0498 (1.487-1.509) Hypertension 2.849 (2.829-2.869) 1.114 Diabetes mellitus 1.951 (1.935-1.968) 1.106 (1.096-1.116) Heart failure 3.893 (3.857-3.930) 1.434 (1.416-1.452) Ischaemic stroke 2.289 (2.23902.340) 1.140 (1.114-1.165) smoker 0.903 (0.891-0.917) 1.052 (1.036-1.069) Liver disease 1.141 (1.119-1.164) 1.082 (1.059-1.105) Previous myocardial infarction 2.128 (2.082-2.176) (0.880-0.926) Inflammatory 1.036 (1.020-1.052) 0.978 (0.964-0.994) 0.005 Cognitive impairment 2.368 (2.326-2.410) 0.821 (0.807-0.836) Illicit drug use 0.288 (0.263-0.317) 0.940 (0.855-1032) 0.19 Dental 0.855 (0.778- 0.939) 0.001 1.107 (1.008-1.216) 0.03 At 5 (mean years). Figure. Flow Chart